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anti-IRS1 Polyclonal, Thermo Scientific™

IRS1 Polyclonal antibody PA1-1059 from Thermo Scientific™ specifically detects IRS1 in Human and Mouse samples, and it is validated for Western Blot

$367.50 - $367.50

Specifications

Antigen IRS1
Cross Reactivity Human
Cross Reactivity Mouse
Format Purified
Host Species Rabbit
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PA11059

 
pierce biotechnology inc
PA11059
Unlabeled 100μg Each for $367.50
Description & Specifications

Specifications

Antigen IRS1
Cross Reactivity Human
Cross Reactivity Mouse
Format Purified
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues D(631) Y M P M S P K S V S A P Q Q I(646) of human IRS-1.
Isotype IgG
Monoclonal or Polyclonal Polyclonal
Primary or Secondary Primary
Storage Requirements Avoid Freeze/Thaw Cycles

IRS1 Polyclonal antibody PA1-1059 from Thermo Scientific™ specifically detects IRS1 in Human and Mouse samples, and it is validated for Western Blot

Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS-1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS-1 degradation pathways are not well understood. IRS-1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm’s tumors, and adrenal cortical carcinomas, thus making IRS-1 phosphorylation and subsequent degradation an attractive therapeutic option. To date there have been four subtypes identified: IRS-1,2,3, and 4, with IRS-1 being widely expressed.
Host Species: Rabbit
Cross Reactivity: Human, Mouse
Isotype: IgG
Immunogen: Synthetic peptide corresponding to residues D(631) Y M P M S P K S V S A P Q Q I(646) of human IRS-1.
Formulation: 100μg purified Antibody in PBS, with 1mg/ml BSA and 0.05% sodium azide;
Synonyms: Insulin Receptor Substrate-1
Uniprot Accession: P35568, P35569
Gene Symbol: IRS1
Entrez GeneID: 16367, 3667
PA1-1059 detects IRS1 in Human and Mouse samples. PA1-1059 has been successfully used in Western Blot procedures. PA1-1059 The immunogen is Synthetic peptide corresponding to residues D(631) Y M P M S P K S V S A P Q Q I(646) of human IRS-1..

Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly