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anti-IL-2 APC, Clone: JES6-5H4, EMD Millipore™

Rat Monoclonal Antibody

Manufacturer:  Millipore Sigma MABF1505

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Catalog No. MABF1505MI



Description

Description

Specifically detects IL-2 Clone: JES6-5H4 in Mouse samples, and it is validated for Flow Cytometry

The JES6-5H4 antibody binds to mouse Interleukin-2 (IL-2), a 17kDa cytokine that is secreted by activated T cells. This cytokine acts as an autocrine stimulatory factor for T cell proliferation, differentiation and survival, as well as being an effective activator of B cells and inducer of NK cell cytotoxic functions. IL-2 plays a key modulatory role in the differentiation of T cells toward either Th17 or T regulatory (Treg) cell types and is important for Treg cell function. The IL-2 receptor (IL-2R) is a complex consisting of an IL-2R alpha chain (CD25), along with the IL-2R beta chain (CD122) and the common gamma chain (CD132). IL-2 may also bind with low affinity to the T cell surface protein CD25 alone, although this interaction does not induce cell signaling.
Specifications

Specifications

IL-2
JES6-5H4
Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Purified
Rat
IgG2b, κ
25μg
Inflammation, Immunology
Primary
Murine
Flow Cytometry
APC
P04351
Il2, Il-2
Proprietary immunogen
Purified by size-exclusion chromatography
RUO
2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Monoclonal
Documents

For Research Use Only