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GAPDH Mouse anti-Amphibian, Canine, Chicken, Fish, Human, Mouse, Non-human primate, Rabbit, Rat, Clone: 6C5, Invitrogen™ DFS Item

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen LSAM4300

Catalog No. AM4300



Description

Description

The anti-beta-actin monoclonal antibody can be used to analyze beta-actin protein expression in experimental cells by immunofluorescence and western blot and has been specifically used in combination with beta-actin siRNA control to study the specificity

GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) is a catalytic enzyme commonly known to be involved in glycolysis. GAPDH exists as a tetramer of identical 37-kDa subunits and catalyzes the reversible reduction of 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphophate in the presence of NADPH. Apart from playing a key role in glycolysis, GAPDH is ubiquitously expressed and displays other activities unrelated to its glycolytic function. GAPDH is reported to be involved in the processes of DNA replication, DNA repair, nuclear RNA export, membrane fusion and microtubule bundling. Studies provide evidence of GAPDH playing an essential part in gene expression observed in apoptosis and as part of the cellular phenotype of age-related neurodegenerative diseases. Further, GAPDH is involved in other cellular processes ranging from membrane fusion, and neuronal apoptosis in cancer. GAPDH is reported to bind to a variety of other proteins, including the amyloid precursor protein, mutations in which cause some forms of Alzheimer′s disease (AD), and the polyglutamine tracts of Huntingtin, the protein product aberrant forms of which are causative of Huntington′s disease. Associations between GAPDH, actin and tubulin have also be reported. Since GAPDH is expressed at high levels in most tissues, it is useful as protein loading control in Western Blot analysis.
Specifications

Specifications

GAPDH
Monoclonal
1 tube anti-GAPDH antibody
PBS with 0.1% sodium azide; pH 7.4
Q28259, P00356, P04406, P16858, P46406, P04797
Glyceraldehyde-3-Phosphate Dehydrogenase, GAPD, G3PD, G3PDH
Mouse
IgG1
RUO
Antibody
Monoclonal
100009074, 14433, 24383, 2597, 374193, 403755
Immunocytochemistry,Immunofluorescence,Western Blot
6C5
Unconjugated
GAPDH
Liquid
GAPDH
Purified rabbit muscle GAPDH (whole molecule).
Protein A
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Primary
100μg
Amphibian,Canine,Chicken,Fish,Human,Mouse,Non-human primate,Rabbit,Rat
SDS
Documents