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anti-CXCR4/CD184 Clone: 12G5, Thermo Scientific™ Novex™ DFS Item

CXCR4/CD184 Monoclonal antibody AHR1462X from Thermo Scientific™ Novex™ specifically detects CXCR4/CD184 in Human and Non-human primate samples, and it is validated for IHC, IHC (F) and FACS

$375.90 - $537.60

Products
Catalog Number Mfr. No. Price Quantity    

358800

DFS Item
 
life technologies
358800
Each for $375.90

AHR1462X

DFS Item
 
life technologies
AHR1462X
Each for $537.60
Description & Specifications

Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The a-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV biding sites.

AHR1462X detects CXCR4/CD184 in Human and Non-human primate samples. AHR1462X has been successfully used in IHC, IHC (F) and FACS procedures. The immunogen for AHR1462X is sIV-infected SupT1 cells injected into Balb/c mice.

Applications:

FACS, Immunohistochemistry, Immunohistochemistry (Frozen)

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