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anti-Coronin 1a Polyclonal, Thermo Scientific™

Coronin 1a Polyclonal Ab PA1-10007 from Thermo Scientific™ specifically detects Coronin 1a in Hu, Ms and Rt samples, and it is validated for ICC, IF and WB

$522.90 - $522.90

Specifications

Antigen Coronin 1a
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Format Purified
View More Specs
Products
Catalog Number Mfr. No. Conjugate Quantity Price Quantity    

01-670-264

 
pierce biotechnology inc
PA110007
Unlabeled 100μL Each for $522.90

01-670-279

 
pierce biotechnology inc
PA110022
Unlabeled 100μL Each for $522.90
Description & Specifications

Specifications

Antigen Coronin 1a
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Format Purified
Host Species Chicken
Immunogen Purified, recombinant human coronin 1a.
Isotype IgY
Monoclonal or Polyclonal Polyclonal
Primary or Secondary Primary
Storage Requirements avoiding freeze/thaw cycles.

Coronin 1a Polyclonal Ab PA1-10007 from Thermo Scientific™ specifically detects Coronin 1a in Hu, Ms and Rt samples, and it is validated for ICC, IF and WB

Highly conserved coronin family of proteins/actin regulators from WD-repeat superfamily were originally identified in Dictyostelium, wherein, coronin deletions were observed to affect actin-dependent processes, such as phagocytosis, cell motility, and cytokinesis. Coronin-1A (Coro1A) belongs to Type I coronins, almost exclusively expressed in hematopoietic lineages, and plays a key role during T lymphocyte activation, migration, survival, and calcium signaling. Moreover, Coronin-1A has been documented to be dispensable for actin-dependent functions in macrophages. Coro1a-deficient mice have reduced peripheral T cells due to both an impaired survival of naive cells and migrational defects. Both CD4+ and CD8+ T cell subsets are decreased in the periphery of Coro1a-/- mice while thymic cellularity and subpopulations are similar to those observed in wild-type mice. A nonsense mutation in Coro1a has been shown to protect against systemic lupus in a mouse model. Moreover, it has shown that Coro1a is mutated in a thymic egress-deficient mouse strain, but also in a patient with severe combined immunodeficiency (SCID).
Host Species: Chicken
Cross Reactivity: Human, Mouse, Rat
Isotype: IgY
Immunogen: Purified, recombinant human coronin 1a.
Formulation: 100μL purified Antibody in PBS, with 10mM sodium azide;
Synonyms: CLABP, CLIPINA, FLJ41407, HCORO1, MGC117380, TACO, p57
Uniprot Accession: O89053, P31146, Q91ZN1
Gene Symbol: CORO1A
Entrez GeneID: 11151, 12721, 155151
PA1-10007 detects Coronin 1a in Human, Mouse and Rat samples. PA1-10007 has been successfully used in Immunocytochemistry, Immunofluorescence and Western Blot procedures. PA1-10007 The immunogen is Purified, recombinant human coronin 1a..