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MilliporeSigma™ anti-CD4 Red Fluor 710, Clone: RM4-5,
Rat Monoclonal Antibody
Supplier: MilliporeSigma™ MABF1578
Description
Specifically detects CD4 Clone: RM4-5 in Mouse samples, and it is validated for Flow Cytometry
The RM4-5 antibody reacts with mouse CD4, a 55kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta2-domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.The RM4-5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the RM4-5 antibody and an alternative antibody, Anti-Mouse CD4 clone GK1.5, will 'compete' for binding, i.e. RM4-5 antibody is able to block GK1.5 antibody binding to cells. In contrast, RM4-5 antibody does not block the binding of Anti-Mouse CD4 clone RM4-4 to cells.Specifications
CD4 | |
Monoclonal | |
Red Fluor 710 | |
P06332 | |
Rat | |
Purified by size-exclusion chromatography | |
RUO | |
Primary | |
2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze |
Flow Cytometry | |
RM4-5 | |
Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1%Â gelatin, pH 7.2. | |
Cd4 | |
Proprietary immunogen | |
100 μg | |
Inflammation, Immunology | |
Mouse | |
Purified |
For Research Use Only