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anti-CD127 (IL-7Ra) Violer Fluor 450, Clone: A7R34, EMD Millipore™

Rat Monoclonal Antibody

Manufacturer:  Millipore Sigma MABF1511

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Catalog No. MABF1511MI



Description

Description

Specifically detects CD127 (IL-7Ra) Clone: A7R34 in Mouse samples, and it is validated for Flow Cytometry

The A7R34 antibody is specific for mouse CD127, a 60-90kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.The A7R34 antibody may be used as a phenotypic marker for CD127 on immature B cells, on subsets of thymocytes which are double negative (CD4-CD8- ) or single positive (CD4+ or CD8+), and at low levels on mature, peripheral T cells. CD127 is a key marker, when used in combination with CD4 and CD25, to distinguish Treg and effector/memory Treg populations known as T(REM).
Specifications

Specifications

CD127 (IL-7Ra)
A7R34
Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Purified
Rat
Purified by size-exclusion chromatography
RUO
2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Monoclonal
Flow Cytometry
violetFluor 450
P16872
Il7r
Proprietary immunogen
25μg
Inflammation, Immunology
Primary
Murine
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