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anti-CD11c Red Fluor 710, Clone: N418, EMD Millipore™

Armenian Hamster Monoclonal Antibody

Manufacturer:  Millipore Sigma MABF1501

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Catalog No. MABF1501MI



Description

Description

Specifically detects CD11c Clone: N418 in Mouse samples, and it is validated for Flow Cytometry

The N418 antibody reacts with mouse CD11c, also known as integrin alpha X. This 150kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor complex known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The N418 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on some types of activated T cells and intestinal intraepithelial lymphocytes (IEL).
Specifications

Specifications

CD11c
N418
Purified Armenian Hamster monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Purified
Armenian Hamster
IgG
25μg
Inflammation, Immunology
Primary
Murine
Flow Cytometry
Red Fluor 710
Q9QXH4
Itgax
Proprietary immunogen
Purified by size-exclusion chromatography
RUO
2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Monoclonal
Documents

For Research Use Only