$358.07 - $358.07
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
Host Species: MouseClone: 6D12Isotype: IgG1, κCross Reactivity: HumanImmunogen: CBL (NP_005179, 736 a.a. ∽836 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26kDa.
ELISA, Immunoprecipitation, Western Blotting