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BUBR1 Sheep anti-Mouse, Polyclonal, Invitrogen™

Sheep Polyclonal Antibody

Manufacturer:  Invitrogen PA112551

Catalog No. 01-674-790



Description

Description

A suggested positive control for this product is mitotic NIH-3T3 cells.

Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to maligt transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1.
Specifications

Specifications

BUBR1
Polyclonal
Unconjugated
Bub1b
Liquid
BUB1B
Recombit protein corresponding to residues 883-1052 of mouse Bub1b.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Mouse
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.08% sodium azide
Q9Z1S0
BUB1beta, BUBR1, MAD3L, SSK1, hBUBR1
Sheep
IgG
250 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
12236
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