BDNF Polyclonal Antibody, Invitrogen™

Description

BDNF Antibody, PA1-18363, from Invitrogen. Species Reactivity: Human, Rat; Applications: ELISA, Immunohistochemistry, Inhibition Assays, Western Blot.

The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene.
Host Species: Sheep
Cross Reactivity: Human, Rat
Isotype: IgG
Immunogen: Recombinant human BDNF.
Formulation: 500μg purified antibody (1mg/mL) and no preservative
Synonyms: Brain-derived neurotrophic factor, Abrineurin
Uniprot Accession: P23363, P23560
Entrez GeneID: 24225, 627
Gene Symbol: BDNF
By ELISA, this antibody exhibits a cross-reactivity of less than 1% to recombinant human BDNF, NT3 and NT4/5. Use at 1-10µg/ml for inhibition of biological activity in vitro. Use neat for in vivo studies at 2-10µg/ml (ED50). Reconstitute with 500 ul of distilled water. After reconstitution keep aliquots at -20º for a higher stability, and at 4ºC with an appropriate antibacterial agent.

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