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BDNF Polyclonal Antibody, Invitrogen™


BDNF Antibody, PA1-18370, from Invitrogen™. Species Reactivity: Human, Mouse, Rat; Applications: ELISA, Immunohistochemistry.

Manufacturer: pierce biotechnology inc  PA118370

Catalog No. 01-670-622

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Description & Specifications

Specifications

Formulation 20μg purified antibody (1mg/mL) and no preservative
Applications Enzyme Linked Immunosorbent Assay
Applications Immunohistochemistry
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Gene Accession No. P21237, P23363, P23560
Storage Requirements avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Gene ID (Entrez) 12064, 24225, 627
Gene Symbols BDNF
Immunogen A synthetic peptide corresponding to human BDNF protein aa 129-138 (HSDPARRGEL) conjugated to KLH
Isotype IgG
Species Reactivity Human, Mouse, Rat
Gene Alias Brain-derived neurotrophic factor, Abrineurin
Quantity 20μg
Antigen BDNF
Host Species Rabbit
Conjugate Unlabeled
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Format Purified

BDNF Antibody, PA1-18370, from Invitrogen. Species Reactivity: Human, Mouse, Rat; Applications: ELISA, Immunohistochemistry.

BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. BDNF promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Host Species: Rabbit
Cross Reactivity: Human, Mouse, Rat
Isotype: IgG
Immunogen: A synthetic peptide corresponding to human BDNF protein aa 129-138 (HSDPARRGEL) conjugated to KLH
Formulation: 20μg purified antibody (1mg/mL) and no preservative
Synonyms: Brain-derived neurotrophic factor, Abrineurin
Uniprot Accession: P21237, P23363, P23560
Entrez GeneID: 12064, 24225, 627
Gene Symbol: BDNF
The immunogenic sequence is highly conserved among most mammalian species. This antibody exhibits less than 0.1% cross reactivity with mouse NGF, recombinant human NT3 and NT4/5 by dot blot analysis. Reconstitute with 20 ul of distilled water.