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beta Amyloid Rabbit anti-Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA118317

Catalog No. 01-670-570



Description

Description

PA1-18317 detects APP from rat samples. PA1-18317 has been successfully used in immunohistochemistry procedures. The PA1-18317 immunogen is a synthetic peptides corresponding to residuess C-E(145) T H L H W H T V A K E T(157), C-H(388) A H F Q K A K E R L E A K H R E R(405), and C-K(724) K K Q Y T S I H H G V V E(737) of human APP isoform A, conjugated to KLH. Reconstitute with 100 μL of distilled water.

Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer′s disease. Abeta peptide is 40-43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease, beta-secretase (BACE) which is synthesized as a propeptide and must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP, and a membrane-bound remt. The remt protein is processed by another protease, gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. Gamma-secretase is believed to be a multi-subunit complex containing presenilin-1 and 2 as central components. The transmembrane glycoprotein, nicastrin, is associated with presinilins and has been found to bind to the carboxyl-terminus of beta APP and helps to modulate the production of the amyloid beta peptide. Abeta is an extracellular filamentous protein component of amyloid cores, neuritic plaques and is also found as a deposit in neurofibrillary tangles. Alzheimer’s disease, the most common cause of senile dementia, is characterized by abnormal filamentous protein deposits in the brain. Beta amyloid deposits are also detected in Lewy body dementia, Down’s syndrome, amyloidosis (Dutch type), cerebroarterial amyloidosis (cerebral amyloid angiopathy) and in the Guam Parkinson-Dementia complex.
Specifications

Specifications

beta Amyloid
Polyclonal
whole serum with no preservative
P08592
APP, ABPP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP; Protease nexin-II, PN-II, APPI, PreA4, A4, AD1
Rabbit
IgG
RUO
Antibody
Polyclonal
Rat
Immunohistochemistry
Unconjugated
App
Lyophilized
APP
Synthetic peptides corresponding to residuess C-E(145) T H L H W H T V A K E T(157), C-H(388) A H F Q K A K E R L E A K H R E R(405), and C-K(724) K K
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
54226
SDS
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