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anti-Adiponectin Receptor 2 Polyclonal, Thermo Scientific™

Adiponectin Receptor 2 Polyclonal Ab PA1-1071 from Thermo Scientific™ specifically detects Adiponectin Receptor 2 in Ms and Rt samples, and it is validated for WB

$480.90 - $764.40

Specifications

Antigen Adiponectin Receptor 2
Cross Reactivity Mouse
Cross Reactivity Rat
Format Purified
Host Species Rabbit
View More Specs
Products
Catalog Number Mfr. No. Conjugate Quantity Price Quantity    

PA11071

 
pierce biotechnology inc
PA11071
Unlabeled 100μg Each for $480.90

01-674-881

 
pierce biotechnology inc
PA112759
Unlabeled 100μg Each for $764.40
Description & Specifications

Specifications

Antigen Adiponectin Receptor 2
Cross Reactivity Mouse
Cross Reactivity Rat
Format Purified
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues D M F A T P Q Y R G V R of mouse Adiponectin Receptor 2.
Isotype IgG
Monoclonal or Polyclonal Polyclonal
Primary or Secondary Primary
Storage Requirements Avoid Freeze/Thaw Cycles

Adiponectin Receptor 2 Polyclonal Ab PA1-1071 from Thermo Scientific™ specifically detects Adiponectin Receptor 2 in Ms and Rt samples, and it is validated for WB

Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR- . Here we report the cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) by expression cloning. AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. These two adiponectin receptors are predicted to contain seven transmembrane domains, but are structurally and functionally distinct from G-protein-coupled receptors. Expression of AdipoR1/R2 or suppression of AdipoR1/R2 expression by small-interfering RNA supports our conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR- ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin.
Host Species: Rabbit
Cross Reactivity: Mouse, Rat
Isotype: IgG
Immunogen: Synthetic peptide corresponding to residues D M F A T P Q Y R G V R of mouse Adiponectin Receptor 2.
Formulation: 100μg purified Antibody (1mg/mL) in PBS, with 1mg/ml BSA and 0.05% sodium azide;
Synonyms: ADIPOR2, ACDCR2, Adiponectin receptor protein 2, FLJ21432, MGC4640, PAQR2, Progestin and adipoQ receptor family member II
Uniprot Accession: Q8BQS5
Gene Symbol: Adipor2
Entrez GeneID: 68465
PA1-1071 detects Adiponectin Receptor 2 in Mouse and Rat samples. PA1-1071 has been successfully used in Western Blot procedures. PA1-1071 The immunogen is Synthetic peptide corresponding to residues D M F A T P Q Y R G V R of mouse Adiponectin Receptor 2..