Acinus Polyclonal Antibody, Invitrogen™
Acinus Antibody, PA1-12496, from Invitrogen™. Species Reactivity: Human; Applications: Western Blot.
Manufacturer: Pierce Biotechnology Inc PA112496
Acinus Antibody, PA1-12496, from Invitrogen. Species Reactivity: Human; Applications: Western Blot.Chromatin condensation and nuclear fragmentation (CCNF)is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed.
Host Species: Rabbit
Cross Reactivity: Human
Immunogen: Synthetic peptide (TRTALHGVKWPQSNPK) corresponding to aa 1065-1080 of human AcinusL, 338-353 of human AcinusS' or 307-322 of human AcinusS. Sequence is located near the C-terminus of the cleaved active peptide p17.
Formulation: 100μg purified antibody in PBS and 0.02% sodium azide
Synonyms: Apoptotic chromatin condensation inducer in the nucleus
Uniprot Accession: Q9UKV3
Entrez GeneID: 22985
Gene Symbol: ACIN1
A suggested positive control for this product is K562 cell lysate.
|338-353 of human AcinusS' or 307-322 of human AcinusS. Sequence is located near the C-terminus of the cleaved active peptide p17.|
|Avoid Freeze/Thaw Cycles|
|100μg purified antibody in PBS and 0.02% sodium azide|
|Apoptotic chromatin condensation inducer in the nucleus|
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