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ABCC2 (M01A), Mouse anti-Human, Clone: 1C5, Abnova™
Mouse monoclonal antibody raised against a partial recombinant ABCC2.
Supplier: Abnova Corporation H00001244M01A
Description
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq
Sequence: LKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKASpecifications
| ABCC2 | |
| Monoclonal | |
| Unconjugated | |
| ascites with no preservative | |
| NM_000392 | |
| ABCC2 | |
| ABCC2 (NP_000383, 214 a.a. ∼ 313 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| RUO | |
| 1244 | |
| Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. | |
| Liquid |
| ELISA, Western Blot | |
| 1C5 | |
| Mouse monoclonal antibody raised against a partial recombinant ABCC2. | |
| ABCC2 | |
| ABC30/CMOAT/DJS/KIAA1010/MRP2/cMRP | |
| Mouse | |
| 200 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 κ |