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Thermo Scientific™ Lab Vision™ Amphiregulin Ab-2, Rabbit Polyclonal Antibody

Obtain accurate, reproducible results in western blotting and Immunoprecipitation experiments with Thermo Scientific™ Amphiregulin Ab-2, Rabbit Polyclonal Antibody.

$227.33 - $1,145.82

Specifications

Antigen Amphiregulin Ab-2
Concentration 1mg/mL
Applications Immunoprecipitation
Classification Polyclonal
Conjugate Unlabeled
View More Specs
Products
Catalog Number Mfr. No. Formulation Quantity Price Quantity    

RB258P

 
thermo scientific™ lab vision™
RB-258-P
Purified Ab with BSA and Azide 1mL Each for $1,043.27

RB258P0

 
thermo scientific™ lab vision™
RB-258-P0
Purified Ab with BSA and Azide 100µL Each for $227.33

RB258P1

 
thermo scientific™ lab vision™
RB-258-P1
Purified Ab with BSA and Azide 500µL Each for $692.22

RB258P1ABX

 
thermo scientific™ lab vision™
RB258P1ABX
Ab without BSA/Azide (Frozen) 500µL Each for $761.67

RB258PABX

 
thermo scientific™ lab vision™
RB-258-PABX
Ab without BSA/Azide (Frozen) 1mL Each for $1,145.82
Description & Specifications

Specifications

Antigen Amphiregulin Ab-2
Concentration 1mg/mL
Applications Immunoprecipitation
Classification Polyclonal
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Host Species Rabbit
Regulatory Status RUO
Research Discipline EGFR Family
Type Primary
Immunogen A synthetic 19-mer peptide, corresponding to aa 26-44 from the secreted amphiregulin of human origin
Isotype IgG

Obtain accurate, reproducible results in western blotting and immunoprecipitation experiments with Thermo Scientific™ Amphiregulin Ab-2, Rabbit Polyclonal Antibody.

 

Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252-amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGFα, AR, HB-EGF, cripto-1, epiregulin, and βcellulin. All of these growth factors contain a characteristic EGF-like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human and Mouse. Others not tested.

Epitope: aa 26-44

Immunogen: A synthetic 19-mer peptide, corresponding to aa 26-44 from the secreted amphiregulin of human origin

Molecular Weight: 18.5-22.5kDa

Positive Control: HT29, LS174T cells

Cellular Localization: Cytoplasmic and/or nuclear

Recommended for:

  • Western Blotting
  • Immunoprecipitation (Native verified)

Note:

USA: RUO; Int'l: RUO