Thermo Scientific™ Lab Vision™ Amphiregulin Ab-2, Rabbit Polyclonal Antibody
Obtain accurate, reproducible results in western blotting and Immunoprecipitation experiments with Thermo Scientific™ Amphiregulin Ab-2, Rabbit Polyclonal Antibody.
Manufacturer: Thermo Scientific™ Lab Vision™ RB258P1ABX
Obtain accurate, reproducible results in western blotting and immunoprecipitation experiments with Thermo Scientific™ Amphiregulin Ab-2, Rabbit Polyclonal Antibody.
Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252-amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGFα, AR, HB-EGF, cripto-1, epiregulin, and βcellulin. All of these growth factors contain a characteristic EGF-like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.
Host Species: Rabbit
Species Reactivity: Human and Mouse. Others not tested.
Epitope: aa 26-44
Immunogen: A synthetic 19-mer peptide, corresponding to aa 26-44 from the secreted amphiregulin of human origin
Molecular Weight: 18.5-22.5kDa
Positive Control: HT29, LS174T cells
Cellular Localization: Cytoplasmic and/or nuclear
- Western Blotting
- Immunoprecipitation (Native verified)
USA: RUO; Int'l: RUO
|Ab without BSA/Azide (Frozen)|
|A synthetic 19-mer peptide, corresponding to aa 26-44 from the secreted amphiregulin of human origin|