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Thermo Scientific™ Lab Vision™ Amphiregulin Ab-1, Rabbit Polyclonal Antibody


Obtain accurate, reproducible results in immunoprecipitation experiments with Thermo Scientific™ Amphiregulin Ab-1, Rabbit Polyclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  RB257P1ABX

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Catalog No. RB257P1ABX

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Description & Specifications

Specifications

Antigen Amphiregulin Ab-1
Applications Immunoprecipitation
Classification Polyclonal
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Rabbit
Immunogen A synthetic 19-mer peptide, corresponding to aa 8-26 (VKPPQNKTESENTSDKPKR) from the secreted amphiregulin of human origin
Isotype IgG
Quantity 500µL
Regulatory Status RUO
Research Discipline EGFR Family
Type Primary

Obtain accurate, reproducible results in immunoprecipitation experiments with Thermo Scientific™ Amphiregulin Ab-1, Rabbit Polyclonal Antibody.

Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252-amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGFalpha, AR, HB-EGF, cripto-1, epiregulin, and beta cellulin. All of these growth factors contain a characteristic EGF-like domain which is defined by six evenly spaced cysteine residues that generate three loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.

Host Species: Rabbit

Species Reactivity: Human and Mouse. Others not tested.

Epitope: aa 8-26

Immunogen: A synthetic 19-mer peptide, corresponding to aa 8-26 (VKPPQNKTESENTSDKPKR) from the secreted amphiregulin of human origin

Positive Control: LS174T cells

Cellular Localization: Cytoplasmic and/or nuclear

Recommended for:

  • Immunoprecipitation (Native verified)

Note:

USA: RUO; Int'l: RUO