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Thermo Scientific™ Lab Vision™ Amphiregulin Ab-1, Rabbit Polyclonal Antibody

Obtain accurate, reproducible results in immunoprecipitation experiments with Thermo Scientific™ Amphiregulin Ab-1, Rabbit Polyclonal Antibody.

Manufacturer:  Thermo Scientific™ Lab Vision™ RB257P1ABX

 View more versions of this product

Catalog No. RB257P1ABX


 

Specifications

Description

Obtain accurate, reproducible results in immunoprecipitation experiments with Thermo Scientific™ Amphiregulin Ab-1, Rabbit Polyclonal Antibody.

Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252-amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGFalpha, AR, HB-EGF, cripto-1, epiregulin, and beta cellulin. All of these growth factors contain a characteristic EGF-like domain which is defined by six evenly spaced cysteine residues that generate three loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.

Host Species: Rabbit

Species Reactivity: Human and Mouse. Others not tested.

Epitope: aa 8-26

Immunogen: A synthetic 19-mer peptide, corresponding to aa 8-26 (VKPPQNKTESENTSDKPKR) from the secreted amphiregulin of human origin

Positive Control: LS174T cells

Cellular Localization: Cytoplasmic and/or nuclear

Recommended for:

  • Immunoprecipitation (Native verified)

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

Amphiregulin Ab-1
Polyclonal
Unlabeled
Concentrated
A synthetic 19-mer peptide, corresponding to aa 8-26 (VKPPQNKTESENTSDKPKR) from the secreted amphiregulin of human origin
500μL
EGFR Family
Polyclonal
Immunoprecipitation
1mg/mL
Ab without BSA/Azide (Frozen)
Rabbit
IgG
RUO
Primary
Human