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AIRE Rat anti-Mouse, eFluor 660, Clone: 5H12, eBioscience™

Rat Monoclonal Antibody

$201.55 - $564.05

Specifications

Antigen AIRE
Clone 5H12
Host Species Rat
Gene Alias Autoimmune Regulator
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124412

 
affymetrix
50593480
25μg Each for $201.55

501124413

 
affymetrix
50593482
100μg Each for $564.05
Description & Specifications

Specifications

Antigen AIRE
Clone 5H12
Host Species Rat
Gene Alias Autoimmune Regulator
Species Reactivity Mouse
Applications Flow Cytometry (Intracellular Staining)
Applications Immunohistochemistry (Frozen)
Regulatory Status RUO
Conjugate eFluor 660
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

This 5H12 monoclonal antibody reacts with mouse Autoimmune Regulator (AIRE). This 58kDa transcription factor is highly expressed within the perinuclear region of mature medullary thymic epithelial cells (mTECs). However, expression of AIRE protein in the periphery remains unclear despite the detection of AIRE mRNA in the lymph node, lymphoid stromal cells, monocytes, and dendritic cells. Studies demonstrate that AIRE is involved in thymocyte development, in particular the regulation of tissue-specific antigen expression during negative selection. Other biological functions for AIRE include chemokine expression and antigen presentation.

The 5H12 antibody recognizes mouse AIRE isoforms 1 and 2.