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AIRE Rat anti-Mouse, eFluor 660, Clone: 5H12, eBioscience™

Rat Monoclonal Antibody

$205.90 - $575.65

Specifications

Antigen AIRE
Clone 5H12
Host Species Rat
Gene Alias Autoimmune Regulator
Species Reactivity Mouse
View More Specs

Disclaimers:

For Research Use Only.



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Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501124412 Life Technologies
LS50593480
25μg Each for $205.90
501124413 Life Technologies
LS50593482
100μg Each for $575.65
Specifications

Description

This 5H12 monoclonal antibody reacts with mouse Autoimmune Regulator (AIRE). This 58kDa transcription factor is highly expressed within the perinuclear region of mature medullary thymic epithelial cells (mTECs). However, expression of AIRE protein in the periphery remains unclear despite the detection of AIRE mRNA in the lymph node, lymphoid stromal cells, monocytes, and dendritic cells. Studies demonstrate that AIRE is involved in thymocyte development, in particular the regulation of tissue-specific antigen expression during negative selection. Other biological functions for AIRE include chemokine expression and antigen presentation.

The 5H12 antibody recognizes mouse AIRE isoforms 1 and 2.
Description & Specifications

Specifications

AIRE
Rat
Mouse
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
5H12
Autoimmune Regulator
Flow Cytometry (Intracellular Staining),Immunohistochemistry (Frozen)
eFluor 660
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.2mg/mL