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AIRE Rat anti-Mouse, Clone: 5H12, eBioscience™

Rat Monoclonal Antibody

$158.05 - $259.55

Specifications

Antigen AIRE
Clone 5H12
Host Species Rat
Gene Alias Autoimmune Regulator
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013333

 
affymetrix
14-5934-80
25μg Each for $158.05

5013334

 
affymetrix
14-5934-82
100μg Each for $259.55
Description & Specifications

Specifications

Antigen AIRE
Clone 5H12
Host Species Rat
Gene Alias Autoimmune Regulator
Species Reactivity Mouse
Applications Flow Cytometry
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

This 5H12 monoclonal antibody reacts with mouse Autoimmune Regulator (AIRE). This 58kDa transcription factor is highly expressed within the perinuclear region of mature medullary thymic epithelial cells (mTECs). However, expression of AIRE protein in the periphery remains unclear despite the detection of AIRE mRNA in the lymph node, lymphoid stromal cells, monocytes, and dendritic cells. Studies demonstrate that AIRE is involved in thymocyte development, in particular the regulation of tissue-specific antigen expression during negative selection. Other biological functions for AIRE include chemokine expression and antigen presentation.

The 5H12 antibody recognizes mouse AIRE isoforms 1 and 2.