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AIRE Rat anti-Mouse, Alexa Fluor 488, Clone: 5H12, eBioscience™

Rat Monoclonal Antibody

$201.55 - $564.05

Specifications

Antigen AIRE
Clone 5H12
Host Species Rat
Gene Alias Autoimmune Regulator
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

50246081

 
affymetrix
53593480
25μg Each for $201.55

50246082

 
affymetrix
53593482
100μg Each for $564.05
Description & Specifications

Specifications

Antigen AIRE
Clone 5H12
Host Species Rat
Gene Alias Autoimmune Regulator
Species Reactivity Mouse
Applications Flow Cytometry
Applications Immunohistochemistry (Frozen)
Regulatory Status RUO
Conjugate Alexa Fluor 488
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

This 5H12 monoclonal antibody reacts with mouse Autoimmune Regulator (AIRE). This 58kDa transcription factor is highly expressed within the perinuclear region of mature medullary thymic epithelial cells (mTECs). However, expression of AIRE protein in the periphery remains unclear despite the detection of AIRE mRNA in the lymph node, lymphoid stromal cells, monocytes, and dendritic cells. Studies demonstrate that AIRE is involved in thymocyte development, in particular the regulation of tissue-specific antigen expression during negative selection. Other biological functions for AIRE include chemokine expression and antigen presentation.

The 5H12 antibody recognizes mouse AIRE isoforms 1 and 2.