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AIRE Rat anti-Mouse, Alexa Fluor 488, Clone: 5H12, eBioscience™

Rat Monoclonal Antibody

$183.48 - $513.48

Specifications

Antigen AIRE
Clone 5H12
Host Species Rat
Gene Alias Autoimmune Regulator
Applications Flow Cytometry,Immunohistochemistry (Frozen)
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
50246081 Life Technologies
LS53593480
25μg Each for $183.48
50246082 Life Technologies
LS53593482
100μg Each for $513.48
Specifications

Description

This 5H12 monoclonal antibody reacts with mouse Autoimmune Regulator (AIRE). This 58kDa transcription factor is highly expressed within the perinuclear region of mature medullary thymic epithelial cells (mTECs). However, expression of AIRE protein in the periphery remains unclear despite the detection of AIRE mRNA in the lymph node, lymphoid stromal cells, monocytes, and dendritic cells. Studies demonstrate that AIRE is involved in thymocyte development, in particular the regulation of tissue-specific antigen expression during negative selection. Other biological functions for AIRE include chemokine expression and antigen presentation.

The 5H12 antibody recognizes mouse AIRE isoforms 1 and 2.
Description & Specifications

Specifications

AIRE
Rat
Flow Cytometry,Immunohistochemistry (Frozen)
Alexa Fluor 488
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.5mg/mL
5H12
Autoimmune Regulator
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer