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AIRE Rat anti-Human, Clone: TM-724, eBioscience™

Rat Monoclonal Antibody

$146.52 - $241.56

Specifications

Antigen AIRE
Clone TM-724
Host Species Rat
Gene Alias Autoimmune Regulator
Applications Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Immunohistochemistry (Frozen)
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122791 Life Technologies
LS14953480
25μg Each for $146.52
501122792 Life Technologies
LS14953482
100μg Each for $241.56
Specifications

Description

This TM-724 monoclonal antibody reacts with human Autoimmune Regulator (AIRE). This 58kDa transcription factor is highly expressed within the perinuclear region of mature medullary thymic epithelial cells (mTECs). AIRE mRNA in the periphery has been observed in the lymph node, fetal liver, and intestines. Furthermore expression has been observed in dendritic cells, epithelial cells and PBMCs. Studies demonstrate that AIRE is involved in thymocyte development, in particular the regulation of tissue-specific antigen expression during negative selection. Other biological functions for AIRE include chemokine expression and antigen presentation. As a result of alternative splicing, three isoforms have been reported. The conditions autoimmune–polyendocrinopathy–candiasis–ectodermal–dystrophy (APECED) and autoimmune polyglandular syndrome type 1 (APS-1) arise from mutations in the human AIRE gene.

The TM-724 antibody is predicted to recognize all three isoforms of human AIRE (AIRE-1, AIRE-2, AIRE-3).
Description & Specifications

Specifications

AIRE
Rat
Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Immunohistochemistry (Frozen)
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL
TM-724
Autoimmune Regulator
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer