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Aiolos Mouse anti-Mouse, Clone: 8B2, eBioscience™

Mouse Monoclonal Antibody

$187.05 - $462.55

Specifications

Antigen Aiolos
Clone 8B2
Host Species Murine
Gene Alias IKZF3
Species Reactivity Mouse
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
50245567 Life Technologies
LS14578980
25μg Each for $187.05
50245568 Life Technologies
LS14578982
100μg Each for $462.55
Specifications

Description

This 8B2 monoclonal antibody reacts with mouse Aiolos, a 58kDa member of the Ikaros family of zinc finger transcription factors. Expression of Aiolos is restricted to the lymphoid lineage, with B cells exhibiting the highest levels of expression, followed by NK and T cells. Studies demonstrate that Aiolos forms homodimers or heterodimerizes with Ikaros proteins. Moreover, Aiolos exhibits tyrosine phosphorylation and nuclear localization in response to IL-2 stimulation in T cells. Aiolos plays a role in IL-2-mediated anti-apoptosis by controlling Bcl-2 expression. Finally, Aiolos is involved in B cell development, with upregulation of this transcription factor observed at the pre-BI to pre-BII transition in response to pre-B cell receptor signaling.
Description & Specifications

Specifications

Aiolos
Murine
Mouse
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
8B2
IKZF3
Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL