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Aiolos Mouse anti-Mouse, Clone: 8B2, eBioscience™

Mouse Monoclonal Antibody

$187.05 - $462.55

Specifications

Antigen Aiolos
Clone 8B2
Host Species Mouse
Gene Alias IKZF3
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

50245567

 
affymetrix
14578980
25μg Each for $187.05

50245568

 
affymetrix
14578982
100μg Each for $462.55
Description & Specifications

Specifications

Antigen Aiolos
Clone 8B2
Host Species Mouse
Gene Alias IKZF3
Species Reactivity Mouse
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

This 8B2 monoclonal antibody reacts with mouse Aiolos, a 58kDa member of the Ikaros family of zinc finger transcription factors. Expression of Aiolos is restricted to the lymphoid lineage, with B cells exhibiting the highest levels of expression, followed by NK and T cells. Studies demonstrate that Aiolos forms homodimers or heterodimerizes with Ikaros proteins. Moreover, Aiolos exhibits tyrosine phosphorylation and nuclear localization in response to IL-2 stimulation in T cells. Aiolos plays a role in IL-2-mediated anti-apoptosis by controlling Bcl-2 expression. Finally, Aiolos is involved in B cell development, with upregulation of this transcription factor observed at the pre-BI to pre-BII transition in response to pre-B cell receptor signaling.