Epredia™ Lab Vision™ Adenovirus Type 2 and 5 Ab-5 Mouse Monoclonal Antibody, 200μg/mL, BSA and azide

Description

Adenovirus Ab-5 detects adenovirus serogroups 2 and 5. The adenovirus early gene product E1A is a potent stimulator of cellular proliferation, which when overexpressed can overcome the growth-inhibitory effects of TGF-β. The E1A region encodes a series of related proteins (35-46kDa) with multifuctional capabilities and form a specific complex with the retinoblastoma tumor suppressor gene product (Rb protein). The E1A and E1B regions together comprise the transforming region of adenovirus. While expression of E1A alone is sufficient to immortalize primary cells, complete transformation requires the additional expression of the E1B region. Several conserved regions of E1A are similar to portions of other viral oncoproteins like the HPV-16 and HPV-18 E7 and SV40 large T antigen.

Host Species: Mouse

Clone: M58 + M73

Isotype: IgG2a/κ + IgG2a/κ

Species Reactivity: Adenovirus.

Immunogen: Adenovirus

Positive Control: 293 cells or adenovirus infected tissues

Cellular Localization: Nuclear.

Ab-5 is excellent for staining of formalin-fixed, paraffin-embedded tissues.

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Western Blotting
• Immunofluorescence
• Immunoprecipitation (Native verified)

Note:

USA: RUO; Int'l: RUO