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ACT1 Rat anti-Human, Clone: 9ACT12, eBioscience™

Rat Monoclonal Antibody

$158.05 - $302.28

Specifications

Antigen ACT1
Clone 9ACT12
Host Species Rat
Gene Alias Nuclear Factor kappa B Activator 1, TRAF3 interacting protein 2, TRAF3IP2, CIKS
Species Reactivity Human
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5013028 Life Technologies
LS14404080
25μg Each for $158.05
5013029 Life Technologies
LS14404082
100μg Each for $302.28
Specifications

Description

The monoclonal antibody 9ACT12 reacts with human Act1 (NF-κB activator 1), also known as CIKS (a connection to IkB kinase and stress-activated kinase). Originally cloned for its ability to activate NF-κB and its direct interaction with IKKγ, Act1 has been subsequently shown to play several roles in immunity. In B cells, it is a negative regulator of CD40 and BAFFR signaling affecting reduced survival. This regulation is through direct interaction of Act1 with CD40 or BAFFR and TRAF3. In addition, Act1 is involved in IL-17R signaling. It interacts with IL-17RA through the homotypic SEFIR interaction domain and is critical for downstream NF-κB- and C/EBP-mediated inflammatory responses.
Description & Specifications

Specifications

ACT1
Rat
Human
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
9ACT12
Nuclear Factor kappa B Activator 1, TRAF3 interacting protein 2, TRAF3IP2, CIKS
Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL