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ACT1 Rat anti-Human, Clone: 9ACT12, eBioscience™

Rat Monoclonal Antibody

$158.05 - $332.05

Specifications

Antigen ACT1
Clone 9ACT12
Host Species Rat
Gene Alias Nuclear Factor kappa B Activator 1, TRAF3 interacting protein 2, TRAF3IP2, CIKS
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013028

 
affymetrix
14-4040-80
25μg Each for $158.05

5013029

 
affymetrix
14-4040-82
100μg Each for $332.05
Description & Specifications

Specifications

Antigen ACT1
Clone 9ACT12
Host Species Rat
Gene Alias Nuclear Factor kappa B Activator 1, TRAF3 interacting protein 2, TRAF3IP2, CIKS
Species Reactivity Human
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody 9ACT12 reacts with human Act1 (NF-κB activator 1), also known as CIKS (a connection to IkB kinase and stress-activated kinase). Originally cloned for its ability to activate NF-κB and its direct interaction with IKKγ, Act1 has been subsequently shown to play several roles in immunity. In B cells, it is a negative regulator of CD40 and BAFFR signaling affecting reduced survival. This regulation is through direct interaction of Act1 with CD40 or BAFFR and TRAF3. In addition, Act1 is involved in IL-17R signaling. It interacts with IL-17RA through the homotypic SEFIR interaction domain and is critical for downstream NF-κB- and C/EBP-mediated inflammatory responses.