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Alfa Aesar™ 6,7-Dihydroxycoumarin, 98+%

$71.88 - $256.15

Chemical Identifiers

Chemical Name or Material 6,7-Dihydroxycoumarin
CAS 305-01-1
Molecular Formula C9H6O4
Formula Weight 178.15
MDL Number MFCD00006874
Beilstein 152788
Merck Index 14,3697
Synonym Cichorigenin; Esculetin
View More Specs
Products
Catalog Number Mfr. No. Quantity Price Quantity    

AAA1539303

  SDS
alfa aesar™
A1539303
1g Each for $71.88

AAA1539306

  SDS
alfa aesar™
A1539306
5g Each for $256.15
Description & Specifications

Specifications

Formula Weight 178.15
Quantity 1g
Melting Point ≈270°C (dec.)
Beilstein 152788
Health Hazard 2 GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Molecular Formula C9H6O4
MDL Number MFCD00006874
Health Hazard 3 GHS P Statement
P261-P280-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapors/spray.
Wear protective gloves/protective clothing/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
RTECS Number GN6382500
Chemical Name or Material 6,7-Dihydroxycoumarin
Assay ≥98%
Merck Index 14,3697
Health Hazard 1 Warning
Recommended Storage 2° to 8°C
Synonym Cichorigenin; Esculetin
CAS 305-01-1

Applications
In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.

Solubility
Soluble in DMSO, DMF, diluted alkalies with blue fluorescence, and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid, and hot ethanol.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agents.

Safety and Handling

Warning

GHS P Statement
P261-P280-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapors/spray.
Wear protective gloves/protective clothing/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

2° to 8°C