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6,7-Dihydroxycoumarin, 98+%, Thermo Scientific Chemicals
Supplier: Thermo Scientific Chemicals A1539303
Description
In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsIn the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.
Solubility
Soluble in DMSO, DMF, diluted alkalies with blue fluorescence, and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid, and hot ethanol.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agents.
Specifications
| 6,7-Dihydroxycoumarin | |
| ∼270°C (decomposition) | |
| MFCD00006874 | |
| 152788 | |
| esculetin, 6,7-dihydroxycoumarin, aesculetin, cichorigenin, 6,7-dihydroxy-2h-chromen-2-one, cichoriin aglucon, esculatin, esculetol, esculin aglucon, esculin aglycon | |
| ILEDWLMCKZNDJK-UHFFFAOYSA-N | |
| 6,7-dihydroxychromen-2-one | |
| 5281416 | |
| 178.15 |
| 305-01-1 | |
| C9H6O4 | |
| 1 g | |
| 14,3697 | |
| Soluble in DMSO,DMF,diluted alkalies with blue fluorescence,and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid,and hot ethanol. | |
| C1=CC(=O)OC2=CC(=C(C=C21)O)O | |
| 178.143 | |
| CHEBI:490095 | |
| ≥98% |
Chemical Identifiers
| 305-01-1 | |
| 178.143 | |
| ILEDWLMCKZNDJK-UHFFFAOYSA-N | |
| 5281416 | |
| 6,7-dihydroxychromen-2-one |
| C9H6O4 | |
| MFCD00006874 | |
| esculetin, 6,7-dihydroxycoumarin, aesculetin, cichorigenin, 6,7-dihydroxy-2h-chromen-2-one, cichoriin aglucon, esculatin, esculetol, esculin aglucon, esculin aglycon | |
| CHEBI:490095 | |
| C1=CC(=O)OC2=CC(=C(C=C21)O)O |
Safety and Handling
GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
H315-H319-H335
EINECSNumber : 206-161-5
RTECSNumber : GN6382500
TSCA : No
Recommended Storage : Keep cold
RUO – Research Use Only