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Thermo Scientific Chemicals 5-Azacytidine, 99%
5-Azacytidine, CAS # 320-67-2, is an chemical analog of cytidine that acts as an inhibitor of DNA methyltransferase activity.
Supplier: Thermo Scientific Chemicals 226620010
Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
5-Azacytidine is a chemical analog of the nucleoside cytidine that incorporates into DNA and inhibits DNA methylation
At low doses, 5-azacytidine irreversibly binds the enzyme DNA methyltransferase (DNMT)
Applications
5-Azacytidine has been used for cardiomyocyte differentiation from mesenchymal stem cells
It has been used as a potent DNMT inhibitor in the study of tumor cell proliferation and induction of gene expression following demethylation
5-Azacytidine can globally change histone modification patterns
Specifications
| 5-Azacytidine | |
| 320-67-2 | |
| 100.0 | |
| White | |
| 98.5% min. (HPLC) | |
| C8H12N4O5 | |
| 1 g | |
| +40° (22°C C=1,H2O) | |
| 5-azacytidine, azacitidine, ladakamycin, azacytidine, vidaza, mylosar, azacitidina, azacitidinum, 5-azacitidine, azacitidinum inn-latin | |
| NMUSYJAQQFHJEW-KVTDHHQDSA-N | |
| 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one | |
| 9444 | |
| 244.21 | |
| Crystalline Powder |
| 99% | |
| 98.5 | |
| 228.0°C to 230.0°C | |
| Authentic | |
| Glass bottle | |
| MFCD00006539 | |
| 15, 884 | |
| + 40.00 | |
| Solubility in water: .. Other solubilities: soluble in methanol | |
| NC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O | |
| 244.21 | |
| CHEBI:2038 | |
| 99% |
Chemical Identifiers
| 320-67-2 | |
| 244.21 | |
| NMUSYJAQQFHJEW-KVTDHHQDSA-N | |
| 9444 | |
| 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one |
| C8H12N4O5 | |
| MFCD00006539 | |
| 5-azacytidine, azacitidine, ladakamycin, azacytidine, vidaza, mylosar, azacitidina, azacitidinum, 5-azacitidine, azacitidinum inn-latin | |
| CHEBI:2038 | |
| NC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |
Safety and Handling
GHS H Statement
Harmful if swallowed.
May cause genetic defects.
May cause cancer.
GHS P Statement
IF SWALLOWED: rinse mouth.
Do NOT induce vomiting.
Call a POISON CENTER or doctor/physician if you feel unwell.
Wash face,hands and any exposed skin thoroughly after handling.
Obtain special instructions before us
GHS Signal Word: Danger
EINECSNumber : 206-280-2
RTECSNumber : XZ3017500
RUO – Research Use Only