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5-Azacytidine, 98%, Thermo Scientific Chemicals
Causes DNA demethylation or hemi-demethylation; a powerful mutagen
Supplier: Thermo Scientific Chemicals J6415903
Description
5-Azacytidine, its incorporation into RNA alters RNA synthesis and processing, and results in inhibition of protein synthesis. It has been used as a cancer chemotherapeutic agent. It is a powerful bacteriostatic, antitumor, and mutagenic agent; it also exhibits immunosuppressive, antimitotic, radioprotective, and virostatic effects.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications5-Azacytidine, its incorporation into RNA alters RNA synthesis and processing, and results in inhibition of protein synthesis. It has been used as a cancer chemotherapeutic agent. It is a powerful bacteriostatic, antitumor, and mutagenic agent; it also exhibits immunosuppressive, antimitotic, radioprotective, and virostatic effects.
Solubility
Soluble in water.
Notes
Store in cool, dry conditions in well sealed containers. Keep container tightly closed.
Specifications
| 5-Azacytidine | |
| 226°C to 232°C (decomposition) | |
| C8H12N4O5 | |
| 1 g | |
| 14,890 | |
| Soluble in water. | |
| NC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O | |
| 244.21 | |
| CHEBI:2038 | |
| 98% |
| 320-67-2 | |
| White | |
| MFCD00006539 | |
| 620461 | |
| 5-azacytidine, azacitidine, ladakamycin, azacytidine, vidaza, mylosar, azacitidina, azacitidinum, 5-azacitidine, azacitidinum inn-latin | |
| NMUSYJAQQFHJEW-KVTDHHQDSA-N | |
| 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one | |
| 9444 | |
| 244.2 | |
| Powder |
Chemical Identifiers
| 320-67-2 | |
| 244.21 | |
| NMUSYJAQQFHJEW-KVTDHHQDSA-N | |
| 9444 | |
| 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one |
| C8H12N4O5 | |
| MFCD00006539 | |
| 5-azacytidine, azacitidine, ladakamycin, azacytidine, vidaza, mylosar, azacitidina, azacitidinum, 5-azacitidine, azacitidinum inn-latin | |
| CHEBI:2038 | |
| NC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |
Safety and Handling
GHS H Statement
H340-H350-H302
May cause genetic defects.
May cause cancer.
Harmful if swallowed.
P201-P202-P264b-P270-P281-P301+P312-P308+P313-P330-P501c
H302-H340-H350
EINECSNumber : 206-280-2
RTECSNumber : XZ3017500
TSCA : No
Recommended Storage : Store at -20°C
RUO – Research Use Only