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Alfa Aesar™ 4alpha-Phorbol 12-myristate 13-acetate, 99%

Negative control for phorbol ester activation of protein kinase C

Chemical Identifiers

Chemical Name or Material 4alpha-Phorbol 12-myristate 13-acetate
CAS 63597-44-4
Formula Weight 616.83g/mol
MDL Number MFCD00153860
Merck Index 14,7332
Synonym 4α-PMA
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

AAJ61099LB0

 
alfa aesar™
J61099-LB0
5mg CALL N/A N/A
 Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.

AAJ61099MCR

 
alfa aesar™
J61099-MCR
1mg CALL N/A N/A
 Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.
Description & Specifications

Specifications

Color White
Quantity 5mg
Sensitivity Light Sensitive
Chemical Name or Material 4alpha-Phorbol 12-myristate 13-acetate
CAS 63597-44-4
Physical Form Powder or Film
Assay 99%
Formula Weight 616.83g/mol
MDL Number MFCD00153860
Merck Index 14,7332
Synonym 4α-PMA
Solubility Information Soluble in DMSO, methanol or ethanol; Dilute stock solution into aqueous medium at final concentrations of ∽2 to 5μM
Storage Note 1 -30° to -10°C

Applications
4alpha-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA, a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes.

Solubility
Soluble in DMSO, methanol or ethanol. Dilute stock solution into aqueous medium at final concentrations of ~2-5µM

Notes
Light sensitive. Incompatible with oxidizing agents and heat.

Safety and Handling

-30° to -10°C