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Alfa Aesar™ 4-Nitrobenzenesulfonyl chloride, 97%

$75.39 - $75.39

Chemical Identifiers

Chemical Name or Material 4-Nitrobenzenesulfonyl chloride
CAS 98-74-8
Molecular Formula C6H4ClNO4S
Formula Weight 221.62g/mol
MDL Number MFCD00007445
UN Number UN3261
Beilstein 746543
View More Specs
Products
Catalog Number Mfr. No. Quantity Price Quantity    

AAA1851214

 
alfa aesar™
A18512-14
25g Each for $75.39

AAA1851222

 
alfa aesar™
A18512-22
100g CALL N/A N/A
 Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.

AAA1851236

 
alfa aesar™
A18512-36
500g CALL N/A N/A
 Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.
Description & Specifications

Specifications

Melting Point 76° to 80°C
Boiling Point 143° to 144°C (1.5mmHg)
Quantity 25g
Chemical Name or Material 4-Nitrobenzenesulfonyl chloride
CAS 98-74-8
Assay 97%
Molecular Formula C6H4ClNO4S
Formula Weight 221.62g/mol
MDL Number MFCD00007445
UN Number UN3261
Beilstein 746543
Health Hazard 1 Danger
Health Hazard 2 GHS H Statement
H314-H318
Causes severe skin burns and eye damage.
Causes serious eye damage.
Health Hazard 3 GHS P Statement
P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dust/fume/gas/mist/vapors/spray.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
DOT Information Transport Hazard Class: 8; Packing Group: II; Proper Shipping Name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S.
TSCA TSCA

Applications
4-Nitrobenzenesulfonyl chloride is used as an intermediate for the synthesis of pharmaceuticals like foscmprenavir, darunavir and amprenavir. It is involved in the preparation of N-nosyl-alpha-amino acid for peptide synthesis. It is also used for stereoselective α-glucosylation of partially protected carbohydrates in association with silver tri-fluoromethanesulfonate, N,N-dimethylacetamide and triethylamine. It is widely used for the synthesis of hydroxylamines of sulfadiazine, sulfamethoxazole and [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2′-bipyridine, nbs = 4-nitrobenzenesulfonate).

Solubility
Soluble in toluene, tetrahydrofuran, methylene chloride and ethyl acetate. Insoluble in water.

Notes
Moisture sensitive. Incompatible with strong oxidizing agents and strong bases.

Safety and Handling

Danger

GHS P Statement
P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dust/fume/gas/mist/vapors/spray.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

GHS H Statement
H314-H318
Causes severe skin burns and eye damage.
Causes serious eye damage.