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4-Hydroxyquinazoline, 98%, Thermo Scientific Chemicals
$73.01 - $211.44
Chemical Identifiers
CAS | 491-36-1 |
---|---|
Molecular Formula | C8H6N2O |
Molecular Weight (g/mol) | 146.149 |
MDL Number | MFCD00511302 |
InChI Key | QMNUDYFKZYBWQX-UHFFFAOYSA-N |
Synonym | 4-hydroxyquinazoline, 4-quinazolinol, quinazolin-4-ol, quinazolin-4 3h-one, 4 3h-quinazolinone, 4-quinazolone, 4-quinazolinone, 4 1h-quinazolinone, 4-oxoquinazoline, 3,4-dihydroquinazolin-4-one |
PubChem CID | 63112 |
IUPAC Name | 1H-quinazolin-4-one |
SMILES | C1=CC=C2C(=C1)C(=O)N=CN2 |
Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
AAA1712909
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Thermo Scientific Chemicals
A1712909 |
10 g |
Each for $73.01
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AAA1712918
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Thermo Scientific Chemicals
A1712918 |
50 g |
Each for $211.44
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Description
4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.
Solubility
Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.
Chemical Identifiers
491-36-1 | |
146.149 | |
QMNUDYFKZYBWQX-UHFFFAOYSA-N | |
63112 | |
C1=CC=C2C(=C1)C(=O)N=CN2 |
C8H6N2O | |
MFCD00511302 | |
4-hydroxyquinazoline, 4-quinazolinol, quinazolin-4-ol, quinazolin-4 3h-one, 4 3h-quinazolinone, 4-quinazolone, 4-quinazolinone, 4 1h-quinazolinone, 4-oxoquinazoline, 3,4-dihydroquinazolin-4-one | |
1H-quinazolin-4-one |
Specifications
491-36-1 | |
Odorless | |
MFCD00511302 | |
118473 | |
Soluble in DMSO (100 mM),ethanol,methanol,and water (10 mM). | |
C1=CC=C2C(=C1)C(=O)N=CN2 | |
146.149 | |
146.15 | |
4-Hydroxyquinazoline |
216°C to 219°C | |
C8H6N2O | |
10 g | |
4-hydroxyquinazoline, 4-quinazolinol, quinazolin-4-ol, quinazolin-4 3h-one, 4 3h-quinazolinone, 4-quinazolone, 4-quinazolinone, 4 1h-quinazolinone, 4-oxoquinazoline, 3,4-dihydroquinazolin-4-one | |
QMNUDYFKZYBWQX-UHFFFAOYSA-N | |
1H-quinazolin-4-one | |
63112 | |
98% |
Safety and Handling
GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
H302-H315-H319-H335
EINECSNumber : 207-735-8
RTECSNumber : VA2300000
TSCA : No
Recommended Storage : Ambient temperatures
RUO – Research Use Only