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Alfa Aesar™ 4-Hydroxyquinazoline, 98%

$47.26 - $47.26

Chemical Identifiers

CAS 491-36-1
Molecular Formula C8H6N2O
Formula Weight 146.15
MDL Number MFCD00511302
Beilstein 118473
Synonym 4-Quinazolinol
Chemical Name or Material 4-Hydroxyquinazoline
View More Specs


Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
AAA1712909 SDS Alfa Aesar™
A1712909
10g Each for $47.26
AAA1712918 SDS Alfa Aesar™
A1712918
50g N/A N/A  
Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.
Specifications

Description

Applications
4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.

Solubility
Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.
Description & Specifications

Chemical Identifiers

491-36-1
146.15
118473
4-Hydroxyquinazoline
C8H6N2O
MFCD00511302
4-Quinazolinol

Specifications

Odorless
10g
C8H6N2O
MFCD00511302
4-Quinazolinol
98%
216° to 219°C
491-36-1
146.15
118473
4-Hydroxyquinazoline

Safety and Handling

GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

GHS P Statement
P280h-P305+P351+P338
Wear protective gloves/clothing.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Warning

RTECSNumber : VA2300000