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Alfa Aesar™ 4-Hydroxyquinazoline, 98%

$48.46 - $48.46

Chemical Identifiers

Chemical Name or Material 4-Hydroxyquinazoline
CAS 491-36-1
Molecular Formula C8H6N2O
Formula Weight 146.15g/mol
MDL Number MFCD00511302
Beilstein 118473
Synonym 4-Quinazolinol
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

AAA1712909

 
alfa aesar™
A17129-09
10g Each for $48.46
Description & Specifications

Specifications

Melting Point 216° to 219°C
Quantity 10g
Odor Odorless
Chemical Name or Material 4-Hydroxyquinazoline
CAS 491-36-1
Assay 98%
Molecular Formula C8H6N2O
Formula Weight 146.15g/mol
MDL Number MFCD00511302
Beilstein 118473
Synonym 4-Quinazolinol
Health Hazard 1 Warning
Health Hazard 2 GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Health Hazard 3 GHS P Statement
P280h-P305+P351+P338
Wear protective gloves/clothing.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
RTECS Number VA2300000

Applications
4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.

Solubility
Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.

Safety and Handling

Warning

GHS P Statement
P280h-P305+P351+P338
Wear protective gloves/clothing.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.