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Alfa Aesar™ 4-(Chloromethyl)pyridine hydrochloride, 98%

Chemical Identifiers

Chemical Name or Material 4-(Chloromethyl)pyridine hydrochloride
CAS 1822-51-1
Molecular Formula C6H62N·HCl
Formula Weight 164.04g/mol
MDL Number MFCD00012826
UN Number UN3261
Beilstein 3689154
Synonym 4-Picolyl chloride hydrochloride
View More Specs
Products
Catalog Number Mfr. No. Quantity Price Quantity    

AAA1285922

 
alfa aesar™
A12859-22
100g CALL N/A N/A
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Description & Specifications

Specifications

Melting Point 166° to 171°C
Quantity 100g
Chemical Name or Material 4-(Chloromethyl)pyridine hydrochloride
CAS 1822-51-1
Assay 98%
Molecular Formula C6H62N·HCl
Formula Weight 164.04g/mol
MDL Number MFCD00012826
UN Number UN3261
Beilstein 3689154
Synonym 4-Picolyl chloride hydrochloride
Health Hazard 1 Danger
Health Hazard 2 GHS H Statement
H301-H311-H314-H318-H317
Toxic if swallowed.
Toxic in contact with skin.
Causes severe skin burns and eye damage.
Causes serious eye damage.
May cause an allergic skin reaction.
Health Hazard 3 GHS P Statement
P260-P301+P310-P303+P361+P353-P305+P351+P338-P361-P405-P501a
Do not breathe dust/fume/gas/mist/vapors/spray.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Remove/Take off immediately all contaminated clothing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
DOT Information Transport Hazard Class: 8; Packing Group: III; Proper Shipping Name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S.

Applications
It finds its application as a reagent for protection of carboxyl termini of peptides as 4-picolyl esters, providing a polar ′handle′ which aids in separation and purification of the peptide. The group can be introduced in the presence of a base, e.g. tetramethylguanidine, is stable to acid-catalyzed removal of Cbz protecting group and can be removed by base, Na in liquid ammonia or catalytic hydrogenolysis. It is also applied in conjunction with Amberlyst®15 resin in peptide synthesis. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Solubility
Soluble in water (750 mg/ml at 20°C), soluble in 1N HCl (2.5%), DMSO, and methanol.

Notes
Hygroscopic. Store away from oxidizing agents and bases. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Safety and Handling

Danger

GHS P Statement
P260-P301+P310-P303+P361+P353-P305+P351+P338-P361-P405-P501a
Do not breathe dust/fume/gas/mist/vapors/spray.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Remove/Take off immediately all contaminated clothing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

GHS H Statement
H301-H311-H314-H318-H317
Toxic if swallowed.
Toxic in contact with skin.
Causes severe skin burns and eye damage.
Causes serious eye damage.
May cause an allergic skin reaction.