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Alfa Aesar™ 4-Chloro-2-(methylthio)pyrimidine, 98%

Chemical Identifiers

Chemical Name or Material 4-Chloro-2-(methylthio)pyrimidine
CAS 49844-90-8
Molecular Formula C5H5ClN2S
Formula Weight 160.63g/mol
MDL Number MFCD00006083
UN Number UN1760
Beilstein 118042
Synonym 4-Chloro-2-(methylmercapto)pyrimidine
View More Specs
Products
Catalog Number Mfr. No. Quantity Price Quantity    

AAB2148109

 
alfa aesar™
B21481-09
10g CALL N/A N/A
 Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.

AAB2148118

 
alfa aesar™
B21481-18
50g CALL N/A N/A
 Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.

AAB2148130

 
alfa aesar™
B21481-30
250g CALL N/A N/A
 Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.
Description & Specifications

Specifications

Melting Point ≈−2°C
Boiling Point 118° to 120°C (9mmHg)
Quantity 10g
Flash Point >110°C (230°F)
Chemical Name or Material 4-Chloro-2-(methylthio)pyrimidine
CAS 49844-90-8
Assay 98%
Molecular Formula C5H5ClN2S
Formula Weight 160.63g/mol
MDL Number MFCD00006083
UN Number UN1760
Beilstein 118042
Synonym 4-Chloro-2-(methylmercapto)pyrimidine
Health Hazard 1 Danger
Health Hazard 2 GHS H Statement
H314-H318
Causes severe skin burns and eye damage.
Causes serious eye damage.
Health Hazard 3 GHS P Statement
P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dust/fume/gas/mist/vapors/spray.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
Recommended Storage −30° to −10°C
DOT Information Transport Hazard Class: 8; Packing Group: III; Proper Shipping Name: CORROSIVE LIQUIDS, N.O.S.

Applications
It finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors.

Solubility
Not miscible or difficult to mix in water.

Notes
Moisture sensitive. Store away from oxidizing agents, bases, water/moisture, heat and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep it refrigerated.

Safety and Handling

Danger

GHS P Statement
P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dust/fume/gas/mist/vapors/spray.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

GHS H Statement
H314-H318
Causes severe skin burns and eye damage.
Causes serious eye damage.

−30° to −10°C