Please login to your online account to display your discounted pricing

Alfa Aesar™ 3-Phenylpropionyl chloride, 98%

Chemical Identifiers

Chemical Name or Material 3-Phenylpropionyl chloride
CAS 645-45-4
Molecular Formula C6H5(CH2)2COCl
Formula Weight 168.62
MDL Number MFCD00000748
UN Number UN3265
Beilstein 742586
Synonym Hydrocinnamoyl chloride
View More Specs
Products
Catalog Number Mfr. No. Quantity Price Quantity    

AAA1086009

 
alfa aesar™
A1086009
10g CALL N/A N/A
 Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.

AAA1086030

 
alfa aesar™
A1086030
250g CALL N/A N/A
 Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.
Description & Specifications

Specifications

Formula Weight 168.62
Chemical Name or Material 3-Phenylpropionyl chloride
TSCA TSCA
Odor Acrid
Assay 98%
Molecular Formula C6H5(CH2)2COCl
MDL Number MFCD00000748
CAS 645-45-4
UN Number UN3265
Beilstein 742586
Synonym Hydrocinnamoyl chloride
Health Hazard 1 Danger
Health Hazard 2 GHS H Statement
H314-H318-H332
Causes severe skin burns and eye damage.
Causes serious eye damage.
Harmful if inhaled.
Boiling Point 225°C
Melting Point −7°C
Flash Point 108°C (226°F)
Health Hazard 3 GHS P Statement
P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dust/fume/gas/mist/vapors/spray.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.
Continue rinsing.
IF SWALLOWED: Rinse mouth.
Do NOT induce vomiting.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
DOT Information Transport Hazard Class: 8; Packing Group: II; Proper Shipping Name: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S.
RTECS Number MW5652395
Quantity 10g

Applications
The 3-phenylpropionate (dihydrocinnamoyl) ester has been used as a protecting group in nucleoside synthesis. Used in the synthesis of 1-Phenyl-3-methyl-4-acyl-5- pyrazolones. N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane were prepared by acylation of the appropriate amine with 3-phenylpropionyl chloride followed by reduction of the resulting amide with either LiA1H4. For the preparation of the phenylacetyl (PA) and 3-phenylpropionyl (PP) derivatives, the corresponding amino acids were coupled in the usual manner with phenylacetyl chloride or 3-phenylpropionyl chloride in the presence of either NaOH(PA-LD- and DL-Pgly. 3-Phenylpropionyl chloride (4) was treated with diazomethane to give diazoketone. Allyloxy resin 12 was acylated with 3-phenylpropionyl chloride and treated with 50% TFA for 1 h followed by treatment with Pd(PPh3)4/PPh3 in solution to furnish the desired hydrox- amic acid.

Notes
Moisture Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, amines, alcohols, active metals, bases, water, moisture.

Safety and Handling

Danger

GHS P Statement
P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dust/fume/gas/mist/vapors/spray.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.
Continue rinsing.
IF SWALLOWED: Rinse mouth.
Do NOT induce vomiting.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

GHS H Statement
H314-H318-H332
Causes severe skin burns and eye damage.
Causes serious eye damage.
Harmful if inhaled.