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3-(4-Fluorobenzoyl)propionic acid, 97%, Thermo Scientific Chemicals
Supplier: Thermo Scientific Chemicals A1375514
Description
7-Fluoro-1-tetralone was prepared from 3-(4-fluorobenzoyl)-propionic acid by Wolff-Kishner reduction followed by ring closure with polyphosphoric acid and other substituted 1-tetralones where commercially available. Reduction of 3-(4-fluorobenzoyl)propionic acid with an excess of tert-butylamine borane (TBAB) in the presence of AlCl3 provided 4-(4-fluorophenyl)-1-butanol (87) in 63% yield for the synthesis of LM-1507 sodium salt. Penfluridol 1-[4,4-bis(4-fluorophenyl)butyl]-4-(4-chloro-3-trifluoromethylphenyl)- 4-hydroxypiperidine, C 28 H 27 ClF 5 NO, M r 523.99, mp 105 - 107°C, is obtained by reducing the ketone of 3-(4-fluorobenzoyl)propionic acid into a lactone.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications7-Fluoro-1-tetralone was prepared from 3-(4-fluorobenzoyl)-propionic acid by Wolff-Kishner reduction followed by ring closure with polyphosphoric acid and other substituted 1-tetralones where commercially available. Reduction of 3-(4-fluorobenzoyl)propionic acid with an excess of tert-butylamine borane (TBAB) in the presence of AlCl3 provided 4-(4-fluorophenyl)-1-butanol (87) in 63% yield for the synthesis of LM-1507 sodium salt. Penfluridol 1-[4,4-bis(4-fluorophenyl)butyl]-4-(4-chloro-3-trifluoromethylphenyl)- 4-hydroxypiperidine, C 28 H 27 ClF 5 NO, M r 523.99, mp 105 - 107°C, is obtained by reducing the ketone of 3-(4-fluorobenzoyl)propionic acid into a lactone.
Solubility
Insoluble in water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.
Specifications
3-(4-Fluorobenzoyl)propionic acid | |
99°C to 103°C | |
C10H9FO3 | |
25 g | |
3-4-fluorobenzoyl propionic acid, 4-4-fluorophenyl-4-oxobutanoic acid, 3-4-fluorobenzoyl propanoic acid, haloperidol metabolite iii, unii-v2z6n6jc9z, beta-4-fluorobenzoyl propionic acid, v2z6n6jc9z, 3-p-fluorobenzoyl propionic acid, 4-4-fluoro-phenyl-4-oxo-butyric acid | |
WUYWHIAAQYQKPP-UHFFFAOYSA-N | |
4-(4-fluorophenyl)-4-oxobutanoic acid | |
101359 | |
97% |
366-77-8 | |
Odorless | |
MFCD00002793 | |
958145 | |
Insoluble in water. | |
C1=CC(=CC=C1C(=O)CCC(=O)O)F | |
196.177 | |
196.18 |
Chemical Identifiers
366-77-8 | |
196.177 | |
WUYWHIAAQYQKPP-UHFFFAOYSA-N | |
101359 | |
C1=CC(=CC=C1C(=O)CCC(=O)O)F |
C10H9FO3 | |
MFCD00002793 | |
3-4-fluorobenzoyl propionic acid, 4-4-fluorophenyl-4-oxobutanoic acid, 3-4-fluorobenzoyl propanoic acid, haloperidol metabolite iii, unii-v2z6n6jc9z, beta-4-fluorobenzoyl propionic acid, v2z6n6jc9z, 3-p-fluorobenzoyl propionic acid, 4-4-fluoro-phenyl-4-oxo-butyric acid | |
4-(4-fluorophenyl)-4-oxobutanoic acid |
Safety and Handling
GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
H315-H319-H335
EINECSNumber : 206-679-1
TSCA : No
Recommended Storage : Ambient temperatures
RUO – Research Use Only