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Alfa Aesar™ 2-Methoxyethoxymethyl chloride, 94%

Chemical Identifiers

Chemical Name or Material 2-Methoxyethoxymethyl chloride
CAS 3970-21-6
Molecular Formula C4H9ClO2
Linear Formula CH3O(CH2)2OCH2Cl
Formula Weight 124.57
MDL Number MFCD00000888
UN Number UN1992
Beilstein 1900576
Synonym 1-(Chloromethoxy)-2-methoxyethane; MEM chloride
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

AAL0105006

  SDS
alfa aesar™
L0105006
5g CALL N/A N/A
 Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.

AAL0105014

  SDS
alfa aesar™
L0105014
25g CALL N/A N/A
 Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.
Description & Specifications

Specifications

Formula Weight 124.57
Chemical Name or Material 2-Methoxyethoxymethyl chloride
CAS 3970-21-6
Synonym 1-(Chloromethoxy)-2-methoxyethane; MEM chloride
Assay 94%
Health Hazard 2 GHS H Statement
H350-H226-H315-H319-H335
May cause cancer.
Flammable liquid and vapor.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
MDL Number MFCD00000888
UN Number UN1992
Health Hazard 3 GHS P Statement
P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Avoid breathing dust/fume/gas/mist/vapors/spray.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
Linear Formula CH3O(CH2)2OCH2Cl
Flash Point 54°C (129°F)
Quantity 5g
Molecular Formula C4H9ClO2
Health Hazard 1 Danger
DOT Information Transport Hazard Class: 3; Packing Group: III; Proper Shipping Name: FLAMMABLE LIQUIDS, TOXIC, N.O.S.
Boiling Point 50° to 52°C (13mmHg)
Beilstein 1900576
TSCA TSCA
Recommended Storage −30° to −10°C

Applications
2-Methoxyethoxymethyl chloride, is used as selectively cleaved under aprotic conditions in the presence of a wide range of OH-protected reagents. It is used as an OH-protecting reagent. An examples of the target molecule MEM Chloride is the side chain of roxithromycin. It is also used in the protection of the OH groups in serine and threonine during peptide synthesis. Some of the other applications include have the ability to coordinate to metals, which is thought to accelerate the cleavage by Lewis acids. The chelating ability of the MEM ether also makes it useful as a stereodirecting group in organometallic reactions, first noted in the stereo controlled addition of ɑ-methoxyvinyllithium to a carbonyl in the synthesis of taxusin.

Solubility
It hydrolyzes with water.

Notes
Moisture, Heat, water Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents. Stable under recommended storage conditions.

Safety and Handling

Danger

GHS P Statement
P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Avoid breathing dust/fume/gas/mist/vapors/spray.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

GHS H Statement
H350-H226-H315-H319-H335
May cause cancer.
Flammable liquid and vapor.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

−30° to −10°C