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Alfa Aesar™ 2-Methoxyethoxymethyl chloride, 94%

Chemical Identifiers

Chemical Name or Material 2-Methoxyethoxymethyl chloride
CAS 3970-21-6
Molecular Formula C4H9ClO2
Linear Formula CH3O(CH2)2OCH2Cl
Formula Weight 124.57g/mol
MDL Number MFCD00000888
UN Number UN1992
Beilstein 1900576
Synonym 1-(Chloromethoxy)-2-methoxyethane; MEM chloride
View More Specs
Products
Catalog Number Mfr. No. Quantity Price Quantity    

AAL0105006

 
alfa aesar™
L01050-06
5g CALL N/A N/A
 Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.

AAL0105014

 
alfa aesar™
L01050-14
25g CALL N/A N/A
 Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.
Description & Specifications

Specifications

Boiling Point 50° to 52°C (13mmHg)
Quantity 5g
Flash Point 54°C (129°F)
Chemical Name or Material 2-Methoxyethoxymethyl chloride
CAS 3970-21-6
Assay 94%
Molecular Formula C4H9ClO2
Linear Formula CH3O(CH2)2OCH2Cl
Formula Weight 124.57g/mol
MDL Number MFCD00000888
UN Number UN1992
Beilstein 1900576
Synonym 1-(Chloromethoxy)-2-methoxyethane; MEM chloride
Health Hazard 1 Danger
Health Hazard 2 GHS H Statement
H350-H226-H315-H319-H335
May cause cancer.
Flammable liquid and vapor.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Health Hazard 3 GHS P Statement
P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Avoid breathing dust/fume/gas/mist/vapors/spray.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
Recommended Storage −30° to −10°C
DOT Information Transport Hazard Class: 3; Packing Group: III; Proper Shipping Name: FLAMMABLE LIQUIDS, TOXIC, N.O.S.
TSCA TSCA

Applications
2-Methoxyethoxymethyl chloride, is used as selectively cleaved under aprotic conditions in the presence of a wide range of OH-protected reagents. It is used as an OH-protecting reagent. An examples of the target molecule MEM Chloride is the side chain of roxithromycin. It is also used in the protection of the OH groups in serine and threonine during peptide synthesis. Some of the other applications include have the ability to coordinate to metals, which is thought to accelerate the cleavage by Lewis acids. The chelating ability of the MEM ether also makes it useful as a stereodirecting group in organometallic reactions, first noted in the stereo controlled addition of ɑ-methoxyvinyllithium to a carbonyl in the synthesis of taxusin.

Solubility
It hydrolyzes with water.

Notes
Moisture, Heat, water Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents. Stable under recommended storage conditions.

Safety and Handling

Danger

GHS P Statement
P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Avoid breathing dust/fume/gas/mist/vapors/spray.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

GHS H Statement
H350-H226-H315-H319-H335
May cause cancer.
Flammable liquid and vapor.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

−30° to −10°C