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2,2-Difluoroacetophenone, 95%, Thermo Scientific Chemicals
Supplier: Thermo Scientific Chemicals H2575006
Description
2,2-Difluoroacetophenone acts as an intermediate in the preparation of various substances such as pharmaceuticals. Further, it is used in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides. In addition to this, it undergoes reduction with (-)-diisopinocampheylchloroborane chloride to get R-alcohols of purity 85% ee.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications2,2-Difluoroacetophenone acts as an intermediate in the preparation of various substances such as pharmaceuticals. Further, it is used in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides. In addition to this, it undergoes reduction with (-)-diisopinocampheylchloroborane chloride to get R-alcohols of purity 85% ee.
Solubility
Immiscible with water.
Notes
Incompatible with strong oxidizing agents and strong acids.
Specifications
| 2,2-Difluoroacetophenone | |
| 48°C to 50°C | |
| Characteristic | |
| 1.4955 | |
| 5 g | |
| Immiscible with water. | |
| C1=CC=C(C=C1)C(=O)C(F)F | |
| 156.132 | |
| 156.13 |
| 395-01-7 | |
| 53°C to 54°C (12 mmHg) | |
| C8H6F2O | |
| MFCD06246879 | |
| 2,2-difluoroacetophenone, alpha,alpha-difluoroacetophenone, 2,2-difluoro-1-phenyl-ethanone, 2,2-difluoro-1-phenylethan-1-one, a,a-difluoroacetophenone, ethanone, 2,2-difluoro-1-phenyl, difluoromethyl phenyl ketone, difluoroacetophenone, acmc-20aojw, acetophenone, 2,2-difluoro | |
| OLYKCPDTXVZOQF-UHFFFAOYSA-N | |
| 2,2-difluoro-1-phenylethanone | |
| 273286 | |
| 95% |
Chemical Identifiers
| 395-01-7 | |
| 156.132 | |
| OLYKCPDTXVZOQF-UHFFFAOYSA-N | |
| 273286 | |
| C1=CC=C(C=C1)C(=O)C(F)F |
| C8H6F2O | |
| MFCD06246879 | |
| 2,2-difluoroacetophenone, alpha,alpha-difluoroacetophenone, 2,2-difluoro-1-phenyl-ethanone, 2,2-difluoro-1-phenylethan-1-one, a,a-difluoroacetophenone, ethanone, 2,2-difluoro-1-phenyl, difluoromethyl phenyl ketone, difluoroacetophenone, acmc-20aojw, acetophenone, 2,2-difluoro | |
| 2,2-difluoro-1-phenylethanone |
Safety and Handling
GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
H315-H319-H335
TSCA : No
Recommended Storage : Ambient temperatures
RUO – Research Use Only