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17-(Allylamino)-17-demethoxygeldanamycin, 99%, Thermo Scientific Chemicals
Possesses anti-tumor activity
$216.51 - $715.86
Chemical Identifiers
| CAS | 75747-14-7 |
|---|---|
| Molecular Formula | C31H43N3O8 |
| Molecular Weight (g/mol) | 585.698 |
| MDL Number | MFCD04973892 |
| InChI Key | AYUNIORJHRXIBJ-MKJFUHJFSA-N |
| Synonym | 17-aag |
| PubChem CID | 133688938 |
| IUPAC Name | [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate |
| SMILES | CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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AAJ66960MB
|
Thermo Scientific Chemicals
J66960MB |
25 mg |
Each for $216.51
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AAJ66960MC
|
Thermo Scientific Chemicals
J66960MC |
100 mg |
Each for $509.71
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AAJ66960EX3
|
Thermo Scientific Chemicals
J66960EX3 |
200 mg |
Each for $715.86
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Description
17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90 (Hsp90), the expression of heat shock factor-1, and the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. In addition to its anti-tumor effects, 17-AAG also induces apoptosis.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
SolubilitySoluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/mL. Very poorly soluble in water
Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.
Chemical Identifiers
| 75747-14-7 | |
| 585.698 | |
| AYUNIORJHRXIBJ-MKJFUHJFSA-N | |
| 133688938 | |
| CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC |
| C31H43N3O8 | |
| MFCD04973892 | |
| 17-aag | |
| [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate |
Specifications
| 75747-14-7 | |
| >110°C (230°F) | |
| MFCD04973892 | |
| Light sensitive | |
| Soluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/ml; Very poorly soluble in water | |
| CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC | |
| 585.698 | |
| 585.69 | |
| Solid |
| 207°C to 209°C | |
| C31H43N3O8 | |
| 25 mg | |
| 17-aag | |
| AYUNIORJHRXIBJ-MKJFUHJFSA-N | |
| [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate | |
| 133688938 | |
| 99% | |
| 17-(Allylamino)-17-demethoxygeldanamycin |
Safety and Handling
RTECSNumber : LX8932000
TSCA : No
storageNote1 : -30° to -10°C
Recommended Storage : Store at -20°C
RUO – Research Use Only