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α-1-Antitrypsin Ab-1 Rabbit Polyclonal Antibody, Epredia™
Obtain accurate, reproducible results with Epredia™ α-1-Antitrypsin Ab-1, Rabbit Polyclonal Antibody.
Supplier: Thermo Fisher Scientific RB367A1
Description
Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
Host Species: Rabbit
Isotype: IgG
Species Reactivity: Human, Baboon, Monkey, Horse and Mink. Does not react with cow, kangaroo, pig, goat, sheep, cat, dog, guinea pig, mouse and chicken. Others not known.
Immunogen: Purified human serum α-1-AT
Positive Control: Tonsil
Cellular Localization: Cytoplasmic
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
Note:
USA: RUO; Int'l: RUO
Specifications
| alpha-1-Antitrypsin Ab-1 | |
| Polyclonal | |
| Rabbit | |
| Tonsil | |
| RUO | |
| Primary | |
| Concentrated |
| Immunohistochemistry (Paraffin) | |
| Unconjugated | |
| Purified human serum alpha-1-AT | |
| 500 μL | |
| Enzyme | |
| Baboon, Equine, Human, Mink | |
| IgG |