Peptide coupling reagent1,1′-Carbonyldiimidazole acts as a coupling reagent and utilized for coupling of amino acids in order to prepare peptide in organic synthesis. It is also used in the preparation of beta-keto sulfones, sulfoxides and beta-enamino acid derivatives. It is used to convert alcohols and amines into carbamates, esters, and ureas. It is involved in the preparation of formylized imidazole by reaction with formic acid. Further, it is used in the synthesis of dipolar polyamides compounds. In addition to this, it is considered as an equivalent of phosgene and used to prepare asymmetric bis alkyl carbonate.
Soluble in dimethylformamide.
Store in a cool place. Incompatible with water, strong acids, strong oxidizing agents, strong bases and amines.
Safety and Handling
GHS H Statement
Causes severe skin burns and eye damage.
Causes serious eye damage.
Harmful if swallowed.
GHS P Statement
Do not breathe dust/fume/gas/mist/vapors/spray.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
DOTInformation : Transport Hazard Class: 8; Packing Group: II; Proper Shipping Name: CORROSIVE SOLID, BASIC, ORGANIC, N.O.S.
TSCA : TSCA
storageNote1 : Moisture sensitive