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Genlantis™ PrimaPure™ Human Aortic Smooth Muscle Cells (HAOSMC) and Kits
Functionally characterized
Supplier: Genlantis™ PH35405A
Description
Human Aortic Smooth Muscle Cells (HAOSMC ) are derived from tunica intima and tunica media of normal human, fibrous plaque-free aorta. They are cryopreserved at second passage and can be cultured and propagated at least 16 population doublings. Arterial smooth muscle cells are capable of synthesizing collagen, elastin, myosin and glycosaminoglycan1,2. Increased production of connective tissue components, hyperplasia and hypertrophy of intimal smooth muscle cells are found to gradually occlude the vessel lumen in atherosclerosis1,2. HAOSMC respond to various factors by proliferating or differentiating3,4. They are a well established cell system for the study of human vascular disorders such as atherosclerosis5,6 and stroke.
- Each lot functionally characterized
- Lots from single donors to allow variability comparisons
- Each lot tested negative for HIV, Hepatitis B & C, mycoplasma, bacteria, yeast, and fungi
- 16 population doublings guaranteed with Genlantis media and reagents
REFERENCES:
1. Abraham, P.A. et al, Biochem. Biophys. Res. Comm. 58:597 (1974).
2. Ross, R., New Engl. J. Med. 314(8):488 (1986).
3. Fager, G. et al, In Vitro Cell. Biol. 25(6):511 (1989).
4. Hoshi, H. et al, In Vitro Cell. Biol. 24(4):309 (1988).
5. Orekhov, A.N. et al, Lab. Invest. 48:749 (1983).
6. Jonasson, L. et al, Arteriosclerosis 6(2):131 (1986).
†Each kit contains an ampoule of cryopreserved HAOSMC (PH35405A), 500mL of Smooth Muscle Cell Growth Medium (PM311500), and a Subculture Reagent Kit (PR090100K).
Specifications
Human Aortic Smooth Muscle Cells (Adult) | |
Smooth Muscle Cell Growth Medium | |
Tunica intima and tunica media of normal human, fibrous plaque-free coronary arteries, pulmonary arteries, aorta |
Used as an experimental model for atherosclerotic lesions | |
>500000 Cells | |
16 Population Doublings |